0000002198 00000 n How to dissolve Hydroquinone to make 4 oz. - ACS Community J. Hydroquinone USP, Eastman - ChemPoint English, J.C. and Deisinger, P.J. These phases (described below) are combined in a mixing tank with an in-line homogenizer as follows. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. When the contents of the reservoir are forced into the reaction chamber, the catalases and peroxidases rapidly break down the hydrogen peroxide and catalyze the oxidation of the hydroquinones into p-quinones. Without being limited to the mechanism of this discoloration, it is believed that the discoloration may be caused at least in part by oxidation of the hydroquinone. The preferred protected retinoid is in the form of small beads or vesicles which are of a form that can be adjusted to be incorporated into varied topical compositions. D7VJV//KZ&t}JSW/L@,l@^ D@ @8 i W `^;V rD}25p>.Bv1}\_E p9 endstream endobj 392 0 obj 1303 endobj 376 0 obj << /Type /Page /Parent 350 0 R /Resources 377 0 R /Contents 381 0 R /MediaBox [ 0 0 595 842 ] /CropBox [ 0 0 595 842 ] /Rotate 0 >> endobj 377 0 obj << /ProcSet [ /PDF /Text ] /Font << /TT2 379 0 R /TT4 383 0 R /TT6 385 0 R >> /ExtGState << /GS1 387 0 R >> /ColorSpace << /Cs6 378 0 R >> >> endobj 378 0 obj [ /ICCBased 386 0 R ] endobj 379 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 252 /Widths [ 250 0 408 500 0 833 778 180 333 333 500 564 250 333 250 278 500 500 500 500 500 500 500 500 500 500 278 278 564 564 564 444 921 722 667 667 722 611 556 722 722 333 389 722 611 889 722 722 556 722 667 556 611 722 722 944 722 722 611 333 0 333 0 500 0 444 500 444 500 444 333 500 500 278 278 500 278 778 500 500 500 500 333 389 278 500 500 722 500 500 444 0 0 0 541 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 333 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 400 0 0 0 0 576 0 0 0 0 0 0 0 750 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 722 0 0 0 0 0 722 0 0 500 444 0 0 0 444 0 0 0 444 444 0 0 0 0 0 0 0 0 0 0 500 0 500 0 0 0 0 0 500 ] /Encoding /WinAnsiEncoding /BaseFont /BCGIOE+TimesNewRoman /FontDescriptor 380 0 R >> endobj 380 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -568 -307 2028 1007 ] /FontName /BCGIOE+TimesNewRoman /ItalicAngle 0 /StemV 94 /XHeight 0 /FontFile2 388 0 R >> endobj 381 0 obj << /Length 462 /Filter /FlateDecode >> stream HYdroquinone can be found in various skin care products. 0000005757 00000 n Determination and Correlation of Solubilities of Benzoic Acid I'm using it for spot treatment of some hyper pigmentation (less than 1% of my body). The protective system can be an entrapment system, a single or multi-laminar system, such as by formation of vesicle, such as a liposome, or by utilizing wax, paraffin, silicone, polyethylene or any material or system which protects the retinoid from oxidation. It has a white-solid appearance. Unfortunately, retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) also have discoloration problems due to oxidation. This range of pH has been preferred for hydroquinone compositions, because it has been believed that the hydroquinone is less likely to excessively discolor under acid conditions. This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. SOLUBILITIES - DrugFuture 65, 5786 (1998), Y.-H. Zhang, Trends Analyt. 43, 13111316 (2007), J. Qing-Zhu, M. Pei-Sheng, Z. Huan, X. Shu-Qian, W. Qiang, Q. Yan, Fluid Phase Equilib. Dietland Muller-Schwarze, 2003, page 43 (, National Institute for Occupational Safety and Health, Additive manufacturing of ceramics from preceramic polymers, http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:31976L0768:EN:HTML, "Clear N Smooth Skin Toning Cream recalled", Skin Bleaching Drug Products for Over-the-Counter Product Use; Proposed Rule, "About the Center for Drug Evaluation and Research - Hydroquinone Studies Under The National Toxicology Program (NTP)", Campaign For Safe Cosmetics - Hydroquinone, "Skin lightening preparations and the hydroquinone controversy", https://en.wikipedia.org/w/index.php?title=Hydroquinone&oldid=1136453324, Wikipedia articles needing page number citations from October 2016, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License 3.0, The most widely used route is similar to the, A potentially significant synthesis of hydroquinone from, Hydroquinone was first obtained in 1820 by the French chemists, Pelletier and Caventou (1820) "Recherches chimiques sur les quinquinas" (Chemical investigations of quinquinas [i.e., the bark of various, This page was last edited on 30 January 2023, at 11:09. I've been presented with the problem of trying to dissolve Hydroquinone in a solvent other than water. Hydroquinone composition - SCHERING CORP - FreePatentsOnline.com At 40C, 4% hydroquinone compositions are more likely to excessively discolor and magnesium ascorbyl phosphate helps to stabilize the color, by preventing the brownish black discoloration and maintaining an amber color. I can only tell you how to mix the powder solution to the liquid solvent. I'd like the consistency to be thin like a gel so that it absorbs quicker. Water Solubility 73000 mg/L at 25C 2.6B pH pKa 4.0 - 4.7 pK1 = 9.9 2.12 Oxidation:Reduction Potential +286 mV at 25C and pH 7 ENVIRONMENTAL FATE/BIODEGRADATION Approved only for prescription use in the U.S. market.Ideal for creams, lotions, and gels for personal care ingredients, pharmaceutical chemical, pharmaceutical excipients, and skin care ingredients. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. sulfur acids, imidic, hydrazonic, hydroximic acids, Carboxylic acids, e.g. These reactions release free oxygen and generate enough heat to bring the mixture to the boiling point and vaporize about a fifth of it, producing a hot spray from the beetle's abdomen. Solubility of Hydroquinone in Different Solvents from - ResearchGate It does not have the same predisposition to cause dermatitis as metol does. 2023 Springer Nature Switzerland AG. https://doi.org/10.1007/s10765-020-02750-4. 1401417, Country of ref document: In the United States, the most commonly used treatment for hyperpigmentation is 1,4-benzenediol, which is known as hydroquinone. So, does anybody know of another solvent I could use that has a higher . HYPERPIGMENTARY STAIN ELIMINATING CREAM FOR FACE SKIN AND ITS USE. Van Haelst, P. Heesen, F. Van Der Wielen, H. Govers, Chemosphere 29, 16511660 (1994), Article endstream endobj 1 0 obj <> endobj 2 0 obj <> endobj 12 0 obj <>stream The preferred protected retinoid is in the form of small beads or vesicles which are of a form that can be adjusted to be incorporated into varied topical compositions. and solubility in water. Re: How to dissolve Hydroquinone to make 4 oz. 0000005306 00000 n Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C 6 H 6 O 2; molecular weight is 110.0. Hydroquinone (C 6 H 4 (OH) 2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. Stir until uniform. Will glycerol and citric acid react? If yes, under what conditions? Some hydroquinone compositions include antioxidants, such as ascorbyl palmitate. Heat Mass Transf. It is a reducing agent that is reversibly oxidized to semiquinone and quinone. An acceptable carrier also possesses suitable aesthetic and cosmetic qualities and may include emollients, conditioners and the like. . Eng. A3, Free format text: ~lgM~Gc{1S_1Q/_/v">S 9 INCI HydroquinoneEastman Hydroquinone, USP is a skin care ingredient used to produce effective skin- lightening applications for depigmentation. Consistent with a condensation reaction, water was determined to be the primary byproduct. Thermodyn. The solubility of sodium phenytoin in binary mixtures of ethanol +water at 298.2, 303.2, 308.2 and 313.2 K was measured. 2017-02-16T09:38:58+01:00 One embodiment of the invention is a composition which comprises hydroquinone (about 1% to about 12%, preferably about 2% to about 10%, more preferably about 2% to about 8%, more preferably with about 2% to about 4%, and most preferably about 3% to about 4%) and has a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. Although about 0.01% sodium metabisulfite without magnesium ascorbyl phosphate may not color stabilize an about 4% hydroquinone composition, and about 0.5% magnesium ascorbyl phosphate without sodium metabisulfite may not either, the combination of sodium metabisulfite and magnesium ascorbyl phosphate in these percentages is effective to stabilize the color of the about 1% to about 12%, about 2% to about 10%, preferably about 2% to about 8% and more preferably about 3% to about 4% and most preferably 4% hydroquinone composition. This is a preview of subscription content, access via your institution. [19][20], In 2006, the United States Food and Drug Administration revoked its previous approval of hydroquinone and proposed a ban on all over-the-counter preparations. Rev. Some documentation and label information may refer to the legacy brand. It is also used to prepare 2% bleaching creams and certain intermediates for the synthesis of dyes, and it has some activity as an antitumoragent. Data 53, 12781282 (2008), A. M1 and M2 microemulsions contain ethanol as co-surfactant. HVoLg~Z+ Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Hope it helps 6 yrs later. Hydrogen peroxide is used and the reaction gives a mixture of hydroquinone and catechol: An accessible route involves the reaction of sodium hydroxide with 1,4-dichlorobenzene. You take the cream, put it in a container, take the powder measurement and add it. 0000002544 00000 n Hydroquinone, 99.5%, Thermo Scientific Chemicals We will respond to you shortly. What is Hydroquinone: Properties, Uses and Applications, Examples PDF HYDROQUINONE - Centers for Disease Control and Prevention It would be desirable to combine the pigmentation disorder treatment with this skin benefit ingredient in one composition. Hydroquinone is a white crystalline solid, poorly soluble in water, but more soluble in organic solvents. Privacy Policy. International Journal of Thermophysics The solubility was increased by addition of ethanol, reached a maximum . PubMedGoogle Scholar. Eastman has active ingredients, thickeners, plasticizers, film formers, and more for your personal care formulations. Hydroquinone is 1,4-benzenediol. Thanks to the added vitamin E, it leaves your skin feeling smooth and soft, too. Eastman Hydroquinone, USP Grade is for skin-lightening products to address hyperpigmentation. For use herein, the encapsulation forms a protective system to prohibit or inhibit the oxidation of the retinoid. vz >I d50dwp?i4,H3. I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. Chim. [21] The FDA officially banned hydroquinone in 2020 as part of a larger reform of the over-the-counter drug review process. One of these, 4-butylresorcinol, has been proven to be more effective at treating melanin-related skin disorders by a wide margin, as well as safe enough to be made available over the counter. endstream endobj 277 0 obj <>stream n3kGz=[==B0FX'+tG,}/Hh8mW2p[AiAN#8$X?AKHI{!7. This invention relates to methods and compositions for the treatment of pigmentation disorders, including hyperpigmentation and vitiligo. Antioxidants in the hydroquinone phase are instrumental in stabilizing the color of the hydroquinone composition. If youd like my help or recipes for this bleaching cream please contact me on Instagram @kaylinell and @kay.linell or Facebook at kay linell. 0000000731 00000 n While the hydroquinone is effective for the pigmentation disorder treatment, retinoid is used for its skin treatment benefits. wG xR^[ochg`>b$*~ :Eb~,m,-,Y*6X[F=3Y~d tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:O:8uJqnv=MmR 4 Hydroquinone - Sciencemadness Wiki We have discovered that a hydroquinone composition (with about 1 to about 12% hydroquinone, preferably with about 2% to about 10%, more preferably with about 2% to about 8%, more preferably with about 2% to about 4%, most preferably with about 3% to about 4% hydroquinone) with preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, can include cationic salts of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate as an antioxidant and the color destabilization problems are appreciably less as compared to hydroquinone compositions without such a cationic salt of acidic ascorbyl esters in the neutral pH range: preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. Adobe Acrobat 10.1.6 Paper Capture Plug-in Additionally, a water-soluble antioxidant, preferably a sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, may be helpful in stabilizing the hydroquinone composition. Why we like it: This affordable cream contains 2 percent hydroquinone, sunscreen, and costs around five dollars. Other properties of hydroquinone are given in Table 1. In the environment, hydroquinone showed increased toxicity for aquatic organisms, being less harmful for bacteria and fungi. Hydroquinone | C6H4(OH)2 - PubChem F. Whler (1844) "Untersuchungen ber das Chinon" (Investigations of quinone). Fill out the form below, and we will send you the document as soon as we can! 0000000807 00000 n I understand the concentrations are high but I have used them before, its just too expensive to keep buying from a compounding pharmacy. Production of Hydroquinone Industrial production of hydroquinone usually happens in two ways. 0000004197 00000 n The correlation coefficient is greater than 0.9937 for one of these two equations for the binary studied systems where the solvent is either water or 1-octanol. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. Have an order or account question? Hydroquinone occurs in the environment as a result of anthropogenic processes, as well as in natural products from plants and animals. N')].uJr Toxicol. uuid:a150f3fd-7f22-4439-aa26-6f445f4017e5 and our We apologize! [31], Hydroquinones are one of the two primary reagents in the defensive glands of bombardier beetles, along with hydrogen peroxide (and perhaps other compounds, depending on the species), which collect in a reservoir. Hydroquinone - an overview | ScienceDirect Topics Hydroquinone is an aromatic organic compound which is currently used in two main sectors: . In another embodiment of the invention, hydroquinone and a protected retinoid are both combined in the composition. 12.4. Additionally, the hydroquinone compositions frequently discolor over time and turn from a whitish color to a brown or even black. This study was funded by Ministre de l'Enseignement Suprieur et de la Recherche Scientifique. COMMON BRAND NAME (S): Aclaro, Aclaro PD, Alera, Alphaquin HP, Alustra, Claripel, Complex B . Hydroquinone is combustible when preheated. [21][25][23] NTP evaluation showed some evidence of long-term carcinogenic and genotoxic effects[26], While hydroquinone remains widely prescribed for treatment of hyperpigmentation, questions raised about its safety profile by regulatory agencies in the EU, Japan, and USA encourage the search for other agents with comparable efficacy. The protective system can be an entrapment system, a single or multi- laminar system, such as by the formation of vesicles such as a liposome or by utilizing wax, paraffin, silicone, polyethylene, or any material or system which protects the retinoid from oxidation. They may also include ingredients with other therapeutic actions, such as anti-inflammatories, antibiotics, exfoliants and peels. Hydroquinone is a white crystalline solid, poorly soluble in water, but more soluble in organic solvents. HyTSwoc [5laQIBHADED2mtFOE.c}088GNg9w '0 Jb I did that by using 1 cup of cream, 4tbsp of hydroquinone and 4tbsp of water or solvent. 115, 22772285 (2014), Article The solubility in water is 6.72g/L. 2017-02-16T10:10:56+01:00 Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. The method of item 1 07 wherein the hydroquinone is present in about 4%. Methods and products for nucleic acid production and delivery, Nucleic acid product and its administration method, Nucleic acid product and method of administration thereof, Compositions and systems for the treatment of hyperpigmentation, Methods for prevention of post-inflammatory hyperpigmentation, Skin care compositions containing retinoids, Improved method for stability of ageing comprising thirosinase inhibitor activity, Use of ascorbic acid to reduce irritation of topically applied active ingredients, COSMETIC COMPOSITIONS WITH ANTIMICOTIC PROPERTIES, EFFECTIVE AGAINST PSORIASIS AND HAIR LOSS AND COSMETIC METHOD FOR, Treatment or prevention of undesired skin pigmentation, Skin care compositions and method of improving skin appearance, Ultrasound enhancement of percutaneous drug absorption, Skin whiteners containing hydroxytetronic acid, Stabilized retinoid-containing skin care compositions, Retinoid compositions containing a water soluble antioxidant and a chelator, Composition and method for treating rosacea and sensitive skin with free radical scavengers, Skin care compositions containing imidazoles and retinoids, Stable compositions containing a retinoid and an enzyme based antioxidant system, Self-tanning compositions containing dha and propolis extract, Composition and process for stabilizing oxygen-unstable species, Bleaching preparation and cosmetic for preventing and improving aging of skin, Composition and method for the treatment of pigmentation disorders, Composition for cosmetic or pharmaceutical use, Remedies for pigmentation and melanocyte proliferation inhibitors, Public reference made under article 153(3) epc to a published international application that has entered the european phase, Divisional application: reference to earlier application, Information on the status of an ep patent application or granted ep patent. - 65.21.225.73. This invention addresses the problem of formulating a pigmentation disorder treatment composition with hydroquinone without an excessive discoloration of the composition in the pH range of about 7.0. Sodium metabisulfite has the added advantage that it does not discolor by oxidation. The drug is freely soluble in water and in alcohol. Solubility of Hydroquinone in Different Solvents from 276.65 K to Azelaic acid - Wikipedia Treatment with hydroquinone interferes with the action of tyrosinase, which is an enzyme used in the synthesis of melanin, and compositions are sold across the counter at about 2% hydroquinone and by prescription at higher concentrations. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), are beneficial for improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. Hydroquinone - Wikipedia P, Kind code of ref document: Provided by the Springer Nature SharedIt content-sharing initiative, Over 10 million scientific documents at your fingertips, Not logged in 58 / Monday, March 26, 2012 / Rules and Regulations 10/31/2017 EN (English US) 6/8 12.3. In 1-octanol, the decreasing order of the solubility of these compounds is as follows: resorcinol>benzoic acid>salicylic acid>hydroquinone. Solubility of Hydroquinone in Different Solvents from 276.65 K to 345. The information given is designed only as a guide for safe handling and use. Continue rinsing.IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.Avoid release to the environment.WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. Hydroquinone occurs as fine, white needles. V)gB0iW8#8w8_QQj@&A)/g>'K t;\ $FZUn(4T%)0C&Zi8bxEB;PAom?W= This chamber is lined with cells that secrete catalases and peroxidases. Formula of hydroquinone is . Determination and Correlation of Solubilities of Benzoic Acid, Salicylic Acid, Resorcinol and Hydroquinone in Water and in 1-Octanol at Temperatures from 297.25K to 334.45K. Glycerol and citric acid, non-toxic and renewable reagents, were crosslinked by a melt polymerization reaction at temperatures from 90-150C. [24], Numerous studies have revealed that hydroquinone, if taken orally, can cause exogenous ochronosis, a disfiguring disease in which blue-black pigments are deposited onto the skin; however, skin preparations containing the ingredient are administered topically. Calorim. Retinoids are included in the invention from about 0.01 to about 5%, preferably from about 0.025% to about 2.0%, more preferably from about 0.05% to about 1%, and most preferably from about 0.025% to about 0.5%. The Molecular Weight is 110.11 g/mol. 2005 Wiley-VCH, Weinheim. Hydroquinone, 99.5%, Thermo Scientific Chemicals 5g, Glass Bottle Quantity: 5g 50g 250g 1kg 5kg Packaging: Glass Bottle Plastic Drum Plastic bottle Description This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. 420, 2429 (2016), W. E. Acree Jr, Thermochim Acta 189, 3756 (1991), F. L. Nordstrm, . C. Rasmuson, J. Chem. According to the polar paradox theory, this should lead to a dissolution of . Some may double boil the hydroquinone and ester, I was too scared of the possibility of combustion. Magnesium ascorbyl phosphate (also called magnesium ascorbityl phosphate or magnesium L-ascorbyl-2-phosphate) has a chemical formula of C. In another embodiment, sodium metabisulfite and magnesium ascorbyl phosphate are used in about 0.01% (preferably from about 0.05% to about 0.5%, most preferably at least about 0.1%,) and about 0.5% (preferably from about 0.25% to about 3%, more preferably from about 0.25% to about 1%, and most preferably at least about 0.5%) respectively in a composition with about 4% hydroquinone. AzA inhibits tyrosinase. endstream endobj 382 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -558 -307 2034 1026 ] /FontName /BCGJCE+TimesNewRoman,Bold /ItalicAngle 0 /StemV 160 /XHeight 0 /FontFile2 389 0 R >> endobj 383 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 181 /Widths [ 250 0 0 0 0 0 0 278 333 333 500 0 250 333 250 278 500 500 500 500 500 500 500 500 500 500 333 333 0 570 0 0 0 722 667 722 722 667 611 778 778 389 500 778 667 944 722 778 611 778 722 556 667 722 722 1000 722 722 0 333 0 333 0 0 0 500 556 444 556 444 333 500 556 278 333 556 278 833 556 500 556 556 444 389 333 556 500 722 500 500 444 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 576 ] /Encoding /WinAnsiEncoding /BaseFont /BCGJCE+TimesNewRoman,Bold /FontDescriptor 382 0 R >> endobj 384 0 obj << /Type /FontDescriptor /Ascent 929 /CapHeight 0 /Descent -249 /Flags 32 /FontBBox [ -184 -249 1037 929 ] /FontName /BCGKAB+ImprintMT-Shadow /ItalicAngle 0 /StemV 0 /FontFile2 390 0 R >> endobj 385 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 122 /Widths [ 250 0 0 0 0 0 0 0 323 323 0 0 0 375 240 0 510 427 510 510 0 510 0 510 510 510 0 0 0 0 0 0 0 729 0 729 0 698 0 0 854 0 0 0 0 927 802 813 0 0 0 604 0 0 0 0 802 0 0 0 0 0 0 0 0 448 552 0 552 448 0 0 573 271 0 0 271 875 573 500 0 552 375 0 323 573 0 0 0 500 448 ] /Encoding /WinAnsiEncoding /BaseFont /BCGKAB+ImprintMT-Shadow /FontDescriptor 384 0 R >> endobj 386 0 obj << /N 3 /Alternate /DeviceRGB /Length 2575 /Filter /FlateDecode >> stream
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