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Glutamate can be used as an energy source when glucose levels the main source of energy are low. 2015;8(2):123-32. Thats why some people get explosive diarrhea, because it stimulates the receptors in the esophagus and small bowel. If you suspect that you have glutamate sensitivity, eliminate as many artificial and natural glutamates and aspartates as possible from your diet until symptoms subside. Both the nervous system and the neurological system are severely impacted if there is excessive glutamate in relation to GABA. 44 (2011) 8392. Silvestrin, R.B., et al. Small quantities of nuts and seeds as snacks. Ding, H., et al. High free glutamates are found in conditions such as: GABA (Gamma-AminoButyric Acid) is an amino acid that regulates the autonomic nervous system which maintains balance between the parasympathetic and sympathetic (fight or flight) nervous systems. Sweets Chewing gums, mints and binders and fillers in many supplements and prescription medications commonly contain either aspartates, aspartames or glutamates as a sweetener or to make the product taste better. GABA normally inhibits brain activity, enabling you to relax. All rights reserved. 2011 Oct; 1(4): 182186. It is mandatory to procure user consent prior to running these cookies on your website. Therefore, the combination of low-grade digestive system inflammation and glutamate sensitivity may combine to create any of the above-mentioned symptoms. Vitamin C is crucial for GABA to inhibit excess glutamate, and lower high copper levels. Exp Ther Med. 2014;34(5):876882. Listing a study does not mean it has been evaluated by the U.S. Federal Government. 4) Lamb and eggs are relatively low. Disclaimer | Privacy Policy | Terms and Conditions | © 2020 True Vitality, Your comments are welcome, however if you wish to contact Sue please. Conditions/symptoms that have been helped by reducing glutamate exposure include: Another neurotransmitter called GABA (gamma-amino-butyric-acid) is the calming, relaxing neurotransmitter that creates balance between the two neurotransmitters (GABA and Glutamate). The low glutamate diet was previously shown to reduce symptoms in fibromyalgia, and thus, was a candidate for this funding. Chicken is quite low while rabbit and turkey are the highest in glutamate. Naaijen, J., et al. Web. Epidemic Answers has not verified and does not guarantee the accuracy of the information provided in this document. Khalifa, D., et al. pecans, walnuts). Gluten-free grains and seeds such as quinoa, amaranth, sesame seeds and flaxmeal. Nuts and seeds. The keto diet is a high-fat, low-carb diet. Examples of these medications are: See a MAPS physician to have your childs GAD levels checked. One mom in California, biochemist Katherine Reid PhD, used her science-based knowledge to create a low-glutamate diet that stabilizes protein and eliminates all inflammatory foods that were excitatory for her daughter with autism. They act and operate exactly like the glutamate receptors in the brain. Also mushrooms, peas and broccoli can come back into the diet, but be aware of any returning symptoms. The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment. Pall, M.L., The Autism Epidemic Is Caused by EMFs, Acting via Calcium Channels and Chemicals Acting via NMDA-Rs: Downstream Effects Cause Autism (conference presentation). Dr. 7. High levels of natural glutamate are found in foods that have been matured, cured or preserved for some time, allowing the proteins to break down to release the glutamate amino acid. Pyridoxine Supplementation Improves the Activity of Recombinant. She is an associate professor in the Department of Health Sciences at American University and is also affiliated with the Center for Behavioral Neuroscience . PMID 15234100. http://www.ncbi.nlm.nih.gov/pubmed/15234100. Continue to avoid soybean products, but some people can tolerate other legumes and beans in small amounts. Eliminate all bottled juices and drinks with a shelf life unless they are freshly squeezed because a ingredients containing glutamates such as citric acid are typically used to preserve them. Glutamate allows chemical messages to be sent between nerve cells. STIMs (self-stimulatory behaviors) such as: Increases production in the brain of alpha waves, slow brain waves that produce a reflective meditative state, Is needed for speech and language production, comprehension, conversation and the pause and space between words, Maintains healthy levels of IgA (antibodies that protect the gut and other mucous linings from harmful foreign toxic matter) which supports a healthy immune system and prevents a , Is needed for action of the pituitary which regulates sleep and HPA axis which regulates stress response, Too much free glutamate coming from dietary sources (believed to be the primary issue), Chronic infections that have crossed the blood-brain barrier, such as seen in. Belcastro V, Gaetano G, Italiano D, Oteri G, Caccamo D, Pisani LR, et al. A typical keto diet consists of 70% . 2015. GABA receptors are found in the gastrointestinal tract and are important for bowel contraction to avoid constipation, abdominal pain and impaired transit. See a visual of the glutamate process at Nutrition Genome here. However, it can also be in an unbound or free form, where it is no longer bound to an amino acid, so it is then digested and absorbed faster by the body, creating a spike of glutamate in the blood which can create damage to our nervous system and beyond. Recommended diets include the modified Atkins diet, ketogenic diet, and low glycemic diet. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. It is better to buy whole fresh foods rather than buy canned or packaged foods that have free glutamates in them. 2019 Feb;108(2):200-201. Adverse effects include constipation, low blood sugar, and gastrointestinal reflux. We dont have to look to far to see children eating foods such as processed meats like devon or similar, or foods with MSG (2-minute noodles for example) plus a no added sugar drink that contains aspartate (diet cola/soda) and as a result have hyperactivity, attention deficit or behavioural issues. Biology and Human Behavior: The Neurological Origins of Individuality, 2nd edition. The longer and slower you cook meat, the more free glutamate is present e.g. Glutamate is one of the most destructive compounds in the brain, but only when it is found in excess outside of brain cells. Seizures (fits, convulsions) are episodes of disturbed brain function that cause changes in attention or behavior. 45 (5): 58395. Others may develop irritable bowel, or if they have irritable bowel, it makes it a lot worse. 13 May 2011. DeHavenon, A., et al. I am seeing first time epileptic dogs within three weeks of starting such diets. 2013;6(1):110. Supplement with N-acetylcysteine (NAC), green tea and omega-3 fatty acids such as cod liver oil to block glutamates. The different treatment options for epilepsy include the following. GABA is found in almost every area of the brain and in very high levels in the hypothalamus. A 2012 study out of Hungarymeasured baseline levels of vitamin D in 13 subjects. Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death. Since 1956, we have been serving the province . Glutamates role in the body is to stimulate our brain cells to deliver messages throughout the body and is particularly important for memory, learning, and general growth and development of the brain, especially for children. There are numerous glutamate receptors in all organs and tissues. Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. Neurochem Int. I have epilepsy since age 4 and when I was around 12 years old my family started a gluten free diet with low sugar, and my seizures stopped (I obly had one seizure, but that one was provoked). Adams, Mike.The Truth About Aspartame, MSG and Excitoxins. For a long time, I wondered about the difference between glutamine and glutamate. Avoid lunch meats because they contain high levels of free glutamates. Poor diet Many seizures take place when blood sugar is low. Because of certain medical conditions or toxicity in the brain, the microglia cells can become stuck in a destructive mode which can lead to neurodegenerative conditions and diseases. Surg Neurol Int. This trial is evaluating whether Low Glutamate diet will improve 3 primary outcomes and 3 secondary outcomes in patients with Aura. Glutamate neuroexcitotoxicity leads to excessive oxidative stress in the brain, causing hyperactivity, seizures and neuronal damage, particularly in the hippocampusthe seat of learning and memory. Another name often associated with glutamine and glutamate is glutamic acid, which is essentially the same as glutamate. Eur J Clin Nutr. Save my name, email, and website in this browser for the next time I comment. Diabetologia. Breakfast (8:00-8:30AM) 1 cup strawberry smoothie + 1 cup cottage cheese + 5-6 tofu pakora. On the flip side, foods that are high in carbohydrates such as any sugary food, bread, and other grain/wheat-based products, most fruits, and beans shouldn't be eaten on the keto diet. Neurohospitalist. 6. Proc Natl Acad Sci U S A. 2019 Jul 24:1362361319866030. Citramate binds to aluminum, which is retained by poor gut flora. In order to post comments, please make sure JavaScript and Cookies are enabled, and reload the page. Supplement with phenylethylamine (PEA) and honokiol to reduce excitotoxicity. Autism Associated With Anti-NMDAR Encephalitis: Glutamate-Related Therapy. Mmmmsuspicious? Some say to avoid corn but small amounts of very fresh corn are ok. Nightshade family of fruits and vegetables such as tomatoes, potatoes, capsicum (peppers), eggplant (aubergine) and chillies/paprika are best avoided initially. Fronto-Striatal Glutamate in Autism Spectrum Disorder and Obsessive Compulsive Disorder. Minimal beef is also fine. 2011. Monosodium glutamate (MSG), which is a common ingredient in processed foods, can cause seizures in mice if it is injected into their bodies. ABSTRACT. Breitenkamp, A.F., et al. 3. Diet drinks and foods Avoid diet drinks and diet foods of any kind that contain any artificial sweeteners such as Nutrasweet, also called Equal or aspartame, aspartate or aspartamine. Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death. 2011 Sep 20;108(38):16050-5. Limit the amount of vitamin D3 because it increases calcium, especially if not taken with vitamin K2. Hassel, B., et al. 2014;121(8):891905. The Teaching Company. PubMed Health. Epilepsy. Epilepsy may be idiopathic, which means the cause cannot be identified. Excitotoxicity can produce many neurological symptoms in children with autism; in fact, autism is considered a hyper-glutamate condition. Can also lead to too much acetylcholine causing: Infections that have crossed the blood-brain barrier (, Brain inflammation stemming from any of the above factors or other factors. Eur Child Adolesc Psychiatry. Sleep-wake cycle manager. Some have even seen those diagnosed with autism change for the better on a low glutamate and aspartate diet. Foods to Eat (low in glutamate and asparate): Anti-convulsant drugs can cause nutrient depletion. Changes in human brain glutamate concentration during hypoglycemia: insights into cerebral adaptations in hypoglycemia-associated autonomic failure in type 1 diabetes. Plausibility of a pathophysiological linkPart I. Autism and EMF? Blaylock, R.L., et al. DSouza, C.E., et al. Avoids the flavour enhancers 620-625 and natural glutamates such as strong cheeses (Parmesan, Camembert, Brie and Gruyere), soy sauce, oyster sauce, black bean sauce, tomato sauce, miso, yeast spread, mushrooms, plums and spinach. But opting out of some of these cookies may affect your browsing experience. . Good gut flora is crucial to GABA production and a healthy gut/brain axis. Epilepsy is a brain disorder involving repeated, spontaneous seizures of any type. 2010 Dec;115(6):1398-408. Supplement with lithium orotate to reduce the amount of glutamate in the brain and promote GABA. MSG is often found in cheaper meat products. Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Alcohol Alcoholic beverages contain glutamate, especially those using mixers of diet soft-drinks/sodas that also contain aspartates. Glutamate is essential for life, but there are many people who are sensitive to it. The industrial producers of glutamate tell us this. Acta Paediatr. Increase magnesium levels to offset calcium levels and stop glutamate misfiring. The Ketogenic diet is used in both children and adults and provides a practical, nonpharmaceutical alternative to anticonvulsant drugs.. Neurochem Int. 4) Nightshades, IF one just can't live without them. For further information on the diet and recommendations of processed foods that do not contain high amounts of free glutamates, please see Dr. Reids pantry list of recommended foods. The G.A.R.D. Keeping a balance between the two is very important otherwise an excess of glutamate over time can cause neurological damage and inflammation to the nerves, which can also lead to neurodegenerative conditions such as: The body normally keeps all the neurotransmitters balanced in the brain, but for some this doesnt always happen. Symptoms of glutamate sensitivity can include headaches, tummy upsets, behavioural disturbances, anxiety and even asthma attacks, which can occur immediately, or even after many hours of digesting glutamate containing foods. Your comments are welcome, however if you wish to contact Sue please click here. 2002; 51(3): 237247. Plausibility of a pathophysiological link Part II. Avoid white rice because free glutamates are involved in the processing of it. The role of glutamate receptors in traumatic brain injury: implications for postsynaptic density in pathophysiology. Excitoxins: The Taste That Kills. dopamine, acetylcholine, glutamate, GABA . Curr Mol Pharmacol. (Source) Wheat Germ Oil. Interview with Dr. Russell Blaylock on Devastating Health Effects of MSG, Aspartame and Excitotoxins. Independent News on Natural Health, Nutrition and More. Glutamine in food is usually drip fed to the body, and through a series of biochemical processes, converted to glutamate daily as needed for repair and regeneration, and to serve the nervous system so that it can function properly. The study is investigating if following the low glutamate diet for 1 month can improve seizure frequency, severity, and duration; cognitive functioning; and/or quality of life, in children with epilepsy. The amount of glutamate and aspartate in a normal serving of meat would normally not be an issue. It is intended for general informational purposes only and should not be relied on to make determinations related to treatment of a medical condition. Glutamate can also be produced artificially and, when combined with sodium to keep it stable, is known as the flavor-enhancer monosodium glutamate, or MSG. While on the diet do not stop any medications or supplements previously prescribed unless advised otherwise by your medical or health care professional. . The ketogenic diet is high in fat with low levels of carbohydrate and protein. Walls, A.B., et al. Low Glutamate Diet for the Treatment of Pediatric Epilepsy Aug 2021 - Mar 2022 Entered clinical data and recruited participants for Dr. Kathleen Holton's Low Glutamate Diet Study for Pediatric . Dairy Products All dairy products are high in glutamate and aspartate. Direct and indirect cellular effects of aspartame on the brain. Youre stimulating all of the glutamate receptors. Yang, Y., et al. about people improving bipolar symptoms with ketogenic or low carb diets . (Oil Wheat Germ) 2006 Jan; 147(Suppl 1): S100S108. Quite a few alternative treatment options are available, and these include herbal supplements, biofeedback, acupuncture, yoga, and breathing exercises. Many people with epilepsy turn to alternative treatment options either alone or in combination with conventional medication. 5. These diets should be carried out with support . Amy Yaskos list of foods with high free glutamates, How to Increase GABA and Balance Glutamate: Article by Amy Yasko PhD, ND biochemist. A study in 2007 showed 44.5 percent of epilepsy patients 45.3 percent of men and 43.7 percent of women were vitamin D deficient, putting these patients at potential increased risk for a wide variety of conditions, including osteoporosis, autoimmune disease, cancer, cardiovascular disease, and infectious disease, among others. The best way to handle this is to only cook bones with no flesh for the broth, and then add some chopped meat to cook towards the end of the process if you would like a meaty flavour. Mol Neurobiol. The interesting part is that all of these different health-issues respond to the same foods being eliminated; it makes one wonder if glutinous grains and cow dairy should be in our diet at all. Use under doctors instructions to catamenial seizures. 2012 Sep;61(4):546-58. Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system. Blaylock MD, Russell. Be sure to keep a daily food diary and be sure to look for improvements or decline in your childs physical, emotional, behavioral and academic symptoms. In fact, EMFs not only cause this flooding of calcium channels, but they can also cause a blood-brain-barrier breech and thus allow infections to invade the brain, leading to PANS/PANDAS. Brain Res Bull. Most fruits and vegetables are great to eat, including green leafy vegies, root vegetables and berries. Choudhury, P.R., et al. Supplement Your Prescription. I've found information about a clinical trial currently being run for this diet. Mol Psychiatry. PLoS One. Lambert, Beth, et al. Enhanced susceptibility to stress and seizures in GAD65 deficient mice. National Library of Medicines list J Neurochem. A ketogenic diet increases the GAD enzyme and neurons can use ketones produced from fat burning as a precursor to GABA. Autism Res. Dev Med Child Neurol. Pyridoxine Supplementation Improves the Activity of Recombinant Glutamate Decarboxylase and the Enzymatic Production of Gama-Aminobutyric Acid. Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with Type I diabetes mellitus. This supplement is especially helpful for diabetics. These include mushrooms, ripe tomatoes, broccoli, walnuts and peas. Chemical messenger. Epileptic Disord. Actual study start date is October 15, 2020. 1994 Jan;17(1):49-53. This is the first study to examine the low glutamate diet in patients with epilepsy. BMC Neurosci. PLoS One. Autism. Soy sauce / tamari (gluten-free soy sauce), Any flavors or flavoring, both natural and artificial, Aspartame (NutraSweet) isnt glutamate but acts in the same manner, Many spice mixes (call the manufacturer if youre not sure). Nightshades The Nightshades family of fruits and vegetables such as tomatoes, potatoes, capsicum (peppers), eggplant (aubergine) and chillies/paprika are best avoided due to their high glutamate levels. Consume only bone broth that has been cooked for only a few hours; longer cooking leads to higher levels of free glutmate. Kash, S.F., et al. The most well known excitotoxin would probably be MSG, an additive that enhances the flavor of food. A diet avoiding glutamates and aspartates is used to help reduce epileptic seizures and many of the symptoms listed above. Other sources When you delve into it, you will be amazed where you can find glutamates, MSG and other additives. Before you commence your diet, see your medical or health care professional for qualified guidance about what foods and supplements are best for your body. 2014 Dec;92(12):1792-800. Cocito, L., et al. Electromagnetic fields act via activation of voltagegated calcium channels to produce beneficial or adverse effects. Glutamate is actually an amino acid that forms part of the building blocks of protein found in all living things. Research suggests that a low-glutamate diet can lower glutamate levels, which may help to alleviate fibromyalgia symptoms. Although there is little evidence that your diet has a direct effect on seizures, a balanced diet provides essential nutrients and keeps our energy levels steady, helping us to stay healthy. Infections in the brain cause brain inflammation and can lead to immunoexcitoxicity. Brain Under Attack: A Resource for Parents and Caregivers of Children with PANS, PANDAS and Autoimmune Encephalitis. Low magnesium levels can lead to seizures. As a practitioner, for years I have used glutamine powder or glutamine rich foods to help heal leaky gut and inflammatory conditions (especially of the gut) with great success. 2017 Nov;42(12):2456-2465. Dr. Reid talked about why symptoms of these disorders may disappear when eating a low-glutamate diet. The Truth About Aspartame, MSG and Excitoxins. Glutamate is an excitatory neurotransmitter, while GABA is an inhibitory neurotransmitter. Rojas, D.C. Many of these are processed foods/ingredients such as: However, even some non-processed foods can contain high levels of glutamate: For more information about foods that contain high amounts of free glutamates, please see The Truth In Labeling Campaigns list of ingredient names used to hide manufactured free glutamate. Health Press, 1996. Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC. The Antianxiety Food Solution: How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood and End Cravings. Chicken is fairly low as well. If someone has acid reflux, it makes that a lot worse. Later, gradually re-introduce some of the more natural sources of glutamate back into your diet. B6 is needed to convert glutamate to GABA. Glutamate and GABA synthesis, release, transport and metabolism as targets for seizure control. Using this information, it may be possible to build up a low glutamate sensitive diet for the long term. Ford, T.C., et al. The most widely employed metabolic therapy is the ketogenic diet, which has been in clinical use for a century (Wheless, 2008). Hence, the epilepsy community would benefit from a dietary option that could reduce/eliminate the drawbacks and side effects of current therapeutic diets, while optimizing micronutrient and antioxidant intake. There are also compounds like potassium glutamate, which can be great for some, but not for glutamate sensitive individuals. 1997;94(25):14060 . The rate at which a food is digested and absorbed also affects its glycemic index . Clinical diagnosis and treatment of pediatric anti-N-methyl-D-aspartate receptor encephalitis: A single center retrospective study. Privacy Policy | Terms of Service | Disclaimer | Website by fuseStarter, We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. (Oil Rice Bran) 0mg in 1 tablespoon. Acta Paediatr. Avoid slow cooking meats because that frees up more glutamates from protein. Here are other recommendations to avoid high free glutamate foods: The daily portions of whole foods are broken down as follows to ensure a healthy nutrient balance in a low glutamate diet: Other factors, including supplements, can increase or decrease glutamate. 2007; 48(10):19901994. Diet and Nutrition Factsheet 20 How does diet affect epilepsy? Glutamate is an amino acid from protein that is a natural and essential part of many common foods that we eat. except for certain brands recommended by Dr. Reid. The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment. [PubMed: 17561949], All MSG found often in restaurants and canned foods, Wheat (30-35% of the protein in wheat is glutamic acid), barley, oats, rye, corn, Artificial sweeteners (NutraSweet, Splenda), Grain-fed meat which is higher in glutamate and aspartate: choose grass-fed meat, especially lamb and eggs which have the lowest glutamate and aspartate, Nuts, beans and seeds very sparingly; avoid nut butters, Potatoes and cauliflower will serve as the best grain substitutes, Tree nuts (e.g. Ripe tomatoes and tomato products (tomato sauce, tomato paste etc), Bone broths and meats cooked for long times, anything hydrolyzed such as hydrolyzed vegetable protein, soy protein (including isolate and concentrate), whey protein (including isolate and concentrate), flavors or flavoring (i.e. Diets aren't just for weight loss. 2012; 78(5):571-579. doi:10.1016/j.mehy . Some individuals are completely legume intolerant. Multiplicity of the antibody response to GAD65 in Type I diabetes. Clin Exp Immunol. 2016 Jul 20;11(7):e0157466. Zhang, Z., et al. An antibiotic called gentamicin has side effects including hearing loss and nerve damage that can lead to seizures. (October 2004). Apparently, glutamate and aspartate consumed together can have even more harmful effects on the nervous systems of young children because of the incomplete myelin sheaths of their nervous system. With this low glutamate diet, Dr. Reids daughter rather quickly extinguished all autism-like behaviors and eventually recovered from autism. Epilepsy may be idiopathic, which means the cause cannot be identified. We are one of the premiere centers in the world for clinical and research expertise on the ketogenic diet, having treated over 1,500 children with this approach. New Harbinger Publications, 2011. By reducing their brains exposure to glutamates, they can reduce the over-stimulation of their brain cells and reduce or remove symptoms. This can be a deadly cocktail of chemicals and sugar (not to mention the alcohol itself). What, how much, and even when we eat all affect the way our brains work. There can be more to autism that this alone of course, but anything that we can do to help is a bonus for those involved. In rodent models, altering glutamate receptor or glutamate transporter expression by knockout or knockdown procedures can induce or suppress epileptic seizures. A host of conditions are associated with a GABA/glutamate imbalance: Excessive glutamates, which come primarily from ones diet, can overstimulate the nervous system and produce adverse neurological symptoms which affect: When the immune system is compromised and not functioning properly, then a GABA/glutamate imbalance becomes more pronounced and problematic. The ketogenic diet is a high-fat, low-carbohydrate, adequate-protein diet that has been used for almost a century in the treatment of epilepsy. Food low in glutamate and asparate: 1) Fruits. Biomed Res Int. Glutamate is also found in significant quantities in other foods that are not matured in any way. By clicking Accept, you consent to the use of. . Wow! Medical Hypotheses. The entire electrical conducting system of the heart is replete with all sorts of glutamate receptors. The ketogenic diet (KD) is defined as a high-fat, low-carbohydrate diet with appropriate amounts of protein, vitamins, and minerals. With this low glutamate diet, Dr. Reid's daughter rather quickly extinguished all "autism-like" behaviors and eventually recovered from autism. The glutamate story. Epidemic Answers Provider Directory to find a practitioner near you. . Names for Monosodium Glutamate (MSG) to Know, Food-Info.net; Review on Monosodium Glutamates; Sylvia de Jong; 2003. This diet aims to improve glutamatergic neurotransmission in the brain by restricting access to dietary free glutamate, while also increasing intake of protective micronutrients and antioxidants, which could serve as a more nutritionally complete dietary option . In normal circumstances, substances like glutamate do not normally cross the blood brain barrier (BBB) to enter the brain. MSG: Deadly Menace in Your Food: Article by Russell Blaylock MD, neurosurgeon, Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system: Peer-reviewed article by Russell Blaylock MD, neurosurgeon, Unblind My Mind: Dr. Reids website gives extensive explanation about the science, a TED talk by Dr. Reid and video tutorials to help parents discern appropriate foods in a local supermarket, The Autism Epidemic Is Caused by EMFs, Acting via Calcium Channels and Chemicals Acting via NMDA-Rs, Excitotoxins, Neurotoxins & Human Neurological Disease Lecture by Russell Blaylock MD, Unblind My Mind: What Are We Eating? Fernell, E. Further studies of GABA and Glutamate imbalances in autism are important challenges for future research. Supplements In most cases nutritional supplements are no cause for concern, however for those who are highly sensitive to glutamates and aspartates, it is wise to avoid supplements that contain glutamine (which can convert to glutamate for some), and to avoid aspartates that are found in mineral supplements like magnesium aspartate, potassium aspartate and the like. Additionally, the low glutamate diet is balanced, nutritious and palatable, with no side effects. Glutamate also allows nerve cells to build associated information, which is a foundation of memory. Database: Standard Release (Common) View. For example, dietary fiber reduces glycemic index. Wang, Hsiuying. EFFECTIVENESS OF THE LOW GLUTAMATE DIET AS AN ADJUNCT TREATMENT FOR PEDIATRIC EPILEPSY By Gabrielle Sarlo Submitted to the Faculty of the College of Arts and Sciences . In addition to epilepsy, modern research has found multiple health-issues linked to gut damage including: alcoholism, arthritis, multiple sclerosis, osteoporosis, Alzheimers, amyotrophic lateral sclerosis, cancer, heart disease, lupus, chronic fatigue, diabetes, schizophrenia, major depression and other mental illnesses, irritable bowel syndrome, migraines, and many more.