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Considering a possible bacterial abscess formation, both patients were started on antibiotics. Also, there is increasing evidence that SARS-CoV-2 could pass to others via fecal-oral transmission. Background: While responses ranged between 5 and 12 days, 65 percent of them reported a return to their usual state of health in about 7 days. Results of a new study published in the American Journal of Gastroenterology indicate that a subset of persons could develop symptoms such as vomiting and diarrhea along with abdominal pain during early stages of infection with SARS -CoV-2, the virus that causes COVID-19. Nausea and vomiting. People infected with Omicron reportedly experience muscle pains in three different body parts: the head, lower back and muscles. See a doctor if you have muscle pain thats severe, persistent, or continues to get worse. While COVID-19 symptoms can vary by individual, three of the most commonly reported symptoms are: Other COVID-19 symptoms typically reported as often as or slightly less than muscle pain include: Another way to determine if your muscle pain is due to COVID-19 is to evaluate when and how it started. It involves resting, icing, compressing, and elevating the affected area. Either type of injury could cause a sharp, sudden pain at the site of the damage. In this Special Feature, we look at what researchers know so far about the prevalence, causes, and effects of COVID-19s GI symptoms. Dr Arora added: "The muscle pain is mainly around the knee area.". Bookshelf However, not all patients with COVID-19 and GI symptoms have symptoms at initial presentation, according to Shapiro. . navigator.sendBeacon('https://www.google-analytics.com/collect', payload); Hepatitis. 1 What is the latest research on the form of cancer Jimmy Carter has? (2021). EatThis.com is part of the AllRecipes Food Group. Modeling the onset of symptoms of COVID-19. It will also be important to confirm whether COVID-19 can spread through feces, and if so, how long this is possible. Abdominal CT scan sh owing bilateral subpleural ground-glass opacities with intralobular reticulations at the lung bases. Meanwhile, researchers also need to learn more about the long-term effects of COVID-19 on the GI tract. A heart attack is a common cause of chest pain, but women may have different symptoms than men. That said, its still important to realize that respiratory symptoms are the more common presentationfever and dry coughas COVID-19 mainly affects the lungs. A study from November 2020 found that having GI symptoms was associated with a heightened risk of developing acute respiratory distress syndrome, as have subsequent studies. Symptoms and diagnosis of pericarditis. The ACE-2 receptor is embedded in cellular membranes. Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. For now, as a meta-analysis published in February 2022 concluded, it seems that GI symptoms and abdominal pain are associated with more severe disease. What are common symptoms of autoimmune disease? In our case series, CT scan findings helped us to suspect the correct diagnosis, which was subsequently confirmed with COVID-19 RT-PCR tests. Tracking GI symptoms in a population may also help identify disease outbreaks before they become apparent. Symptoms such as pain, nausea, and diarrhea may also occur if viruses damage GI tissues. PCS pain typically comes on when a person is at rest or shifting positions. No microbiological pathogen was detected in further investigations (sputum analysis, bronchoscopy with . Abdominal imaging findings on computed tomography in patients acutely infected with SARS-CoV-2: what are the findings? Chest pain when breathing can have many causes that range from mild to more serious. (2018). We avoid using tertiary references. This case series is about three patients who presented to the emergency department of a community hospital in Montpellier, France, with acute abdominal pain. Epub 2020 May 21. You May Have an Upset Stomach. The diagnostic uncertainty for children with abdominal pain has increased during the COVID-19 pandemic with the additional consideration of both COVID-19 and paediatric inflammatory multisystem syndrome-temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS) alongside appendicitis, mesenteric adenitis and If feces containing the new coronavirus can spread the infection, it will also be important to monitor and potentially treat wastewater to reduce transmission. Treasure Island (FL): StatPearls Publishing; 2022 Jan. What can cause chest pain while breathing? (The virus can be active on hard surfaces such as plastic or stainless steel for 2-3 days and cardboard for 1 day) While the virus may potentially be aerosolized via droplets for several hours (< 3 hours), this is not believed to be the primary mode of transmission. Researchers also need to know whether having a preexisting GI disease increases the risk of severe COVID-19, complications, and death. Once inside the cell, the virus uses the cells own machinery to produce copies of viral proteins and RNA. Muscles can become inflamed during any illness, leading to soreness. official website and that any information you provide is encrypted Other symptoms. However, with the new Omicron variant, symptoms have been described as being more similar to a common cold. Unauthorized use of these marks is strictly prohibited. Taya M, Paroder V, Redelman-Sidi G, Gangai N, Golia Pernicka JS, Gollub MJ, Javed-Tayyab S, Petkovska I, Bates DDB. The site is secure. The public and patients should understand that some GI symptoms (such as loose stools up to 3 times per day) may accompany respiratory complaints in almost half of patients. A person should phone the emergency services if they experience any of the symptoms of a heart attack or have an episode of angina that persists for 5 minutes or more following a second dose of angina medication. The pain usually lasts only a few seconds to a few minutes. It is also different from the soreness you would feel after an intense workout. Before "All patients presented with a combination of symptoms including fever, abdominal pain, diarrhoea, and vomiting." RELATED: Vaccine success but there's a catch We've consulted with our team of licensed nutritionists and dietitians to bring you informed recommendations for food products, health aids and nutritional goods to safely and successfully guide you toward making better diet and nutrition choices. (2020). Muscle pain isn't one of the more common symptoms of COVID-19. A report from early in the pandemic reviewed COVID-19 symptoms in 55,924 individuals and found that muscle pain happened in only 14.8 percent of people. Muscle pain isnt one of the more common symptoms of COVID-19. FOIA A heart attack is a severe shortage or complete blockage of blood flow to the heart muscle. The pain may occur in the center of the chest or just left of the center. I didn't know I was sick, Griffin said.After a scan on her appendix and kidneys appeared normal, doctors ran a CT scan on her lungs. Based on data from The WHO, nearly 1 in 6 persons who is diagnosed with COVID-19 will develop severe illness and respiratory compromise that may lead to the need for mechanical ventilation. COVID-19 infections may present as an acute abdominal pain. A report from early in the pandemic reviewed COVID-19 symptoms in 55,924 individuals and found that muscle pain . The Centers for Disease Control and Prevention (CDC) recommend that people self-isolate for 520 days after the onset of COVID-19 symptoms, depending on specific symptoms and their severity. Caruso D, Zerunian M, Pucciarelli F, Lucertini E, Bracci B, Polidori T, Guido G, Polici M, Rucci C, Iannicelli E, Laghi A. BJR Open. Sample case scenarios, exacerbated pain, and long-term convalescence are addressed. COVID-19 causes inflammation throughout the body, and muscle pain is a commonly reported symptom. Other things that may help with muscle pain include: There are a few ways that you can help to prevent both COVID-19 and muscle pain. (2020). 6 Left-sided chest pain can be concerning. eCollection 2021. Epub 2021 Oct 3. 5 Signs That Pain You Have is COVID, According to Doctors, COVID-19 is everywhere, but it doesn't always shout to make its presence known. Omicron sparks inflammation in our bodies, which causes muscle pain, Headches and lower back pain alongside sore muscles are common signs of Omicron. Although these GI complaints may be less urgent than respiratory . Abdominal pain is less common, occurring in less than 10%.. Conclusion and relevance: Watch the video above to learn more about this story. This can cause a variety of symptoms throughout the body, including muscle pain. Some examples of autoimmune conditions that may cause muscle pain are: Specific symptoms may vary by condition. If these symptoms are as common as research suggests, SARS-CoV-2 testing services could widen their reach to include people with appetite loss, vomiting, and diarrhea, with or without respiratory symptoms. Symptoms of COVID-19 typically come on gradually, about 2 to 14 days after exposure to the novel coronavirus. As many as 40% of people infected with the novel coronavirus may never experience symptoms. "COVID toes" may seem to be a weird sign of coronavirus, but skin problems are crazy-common: Up to 20% of people with COVID-19 report skin changes, such as a red, bumpy rash; hives; or breakouts resembling chickenpox. Please enable it to take advantage of the complete set of features! We strive to only recommend products that adhere to our philosophy of eating better while still enjoying what you eat. We avoid using tertiary references. Although its respiratory effects can be deadly and debilitating, it can lead to other systemic disorders, such as those causing eye pain and headache. COVID: Clinical Considerations for Acute and Post-Infection Symptoms. This subset of patients with abdominal pain as their chief presenting symptom also had a more severe course of their illness, while also taking longer to seek medical care. From 112 patients admitted with acute abdominal pain in the absence of respiratory symptoms, 16 (14.3%) tested positive for COVID-19 on RT-PCR swab testing. It's not fun, it's not fun being in a hospital bed, begging the nurse to turn up the oxygen and she says it's up all the way, begging for them to help you breathe. Studies show that SARS-CoV-2 enters intestinal cells and respiratory cells using the angiotensin-converting enzyme 2 (ACE-2) protein as a receptor. Half of these patients represented COVID-19 manifesting primarily as acute abdominal pain. Many GI conditions may also make it easier to develop GI infections because they damage or weaken the intestinal or stomach lining. Heartburn may occur alongside additional symptoms, such as: Occasional heartburn is not usually a cause for concern. Pericarditis is the inflammation of the pericardium, which is the thin membrane of tissue surrounding the heart. Pericarditis causes a sharp, sudden pain in the center or left side of the chest that tends to worsen when a person breathes deeply. Importance: Tummy troubles can indicate COVID, and they may be the only sign you're infected. The .gov means its official. There are also around 100 times more ACE-2 receptors in the GI tract than respiratory organs, so it may be able to house more viruses when it acquires an infection. Learn how it's done and what the results mean. The most common gastrointestinal symptoms are loss of appetite, followed by nausea and vomiting, diarrhea and abdominal pain. Get email updates with the day's biggest stories. Early evidence seems generally consistent. People with viral infection in their respiratory and GI tracts may have been exposed to higher viral loads than people for whom the infection is limited to the respiratory tract. Unable to load your collection due to an error, Unable to load your delegates due to an error. The virus enters intestinal cells after its characteristic spike proteins bind to ACE-2. An official website of the United States government. It can also be a sign of coronavirus. PMC This prevalence is supported by two later systematic reviews that found that muscle pain was reported in between 16.9 percent and 17 percent of individuals with COVID-19. This can happen if you were recently: If you think youve been exposed to COVID-19, get a COVID-19 test. To report that patients who subsequently test positive for COVID-19 may present with acute abdominal pain and no pulmonary symptoms . This results when the injection site is too low or the needle is placed too deeply. Another factor to consider is if youve had a potential exposure to the SARS-CoV-2 virus. Possible side effects after getting a COVID-19 vaccine. method for an area thats injured or overused. Learn how to tell the difference between a heart attack and other potential causes and symptoms. Kidney cancer. This could help identify COVID-19 cases earlier. Griffin still has nine days of quarantine left and she says she still doesn't feel 100%, but her doctors told her she now has antibodies in her system that could help other people, so she's planning to donate blood and plasma as early as next week. day, 2022 Galvanized Media. Pay close attention to your other symptoms as well as their onset and duration to determine if your muscle pain is due to COVID-19. A broken or bruised rib usually heals on its own within 36 weeks. National Library of Medicine Radiology. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Joline Griffin went to a Florida hospital emergency room for severe abdominal pain on March 29 and later found out she had COVID-19. Methods: In addition to muscle aches and pains, some general symptoms of an infection include: Fibromyalgia is a condition that causes pain throughout your body. PMC Some preliminary studies show that certain symptoms may persist for weeks or months after the person has recovered from the initial illness. Keep reading below to learn how to tell if muscle pain is due to COVID-19, what other conditions that can lead to muscle pain, and when to see a doctor. "I think it already is a systemic disease for some peoplewe're just not recognizing the full implications of the pathogenesis and the clinical manifestations," warns Dr. Anthony Fauci, the nation's top infectious disease expert and the director of the National Institute of Allergy and Infectious Diseases. Accessibility Majeed T, Ali RS, Solomon J, Mesri M, Sharma S, Shamim S, Aiynattu S, Ishak R, Wilson J, Magee C. Indian J Surg. The pain may radiate up to the neck. doi: 10.1002/14651858.CD013639.pub5. Some other things that can help to alleviate COVID-19 symptoms include drinking enough fluids and getting plenty of rest. Cureus. In the U.S., there has been an increase in reported cases of myocarditis and pericarditis after mRNA COVID-19 vaccination, particularly in males ages 12 through 29. Side effects from vaccination should go away after a few days. The esophagus is the tube that connects the mouth and stomach. A similar study, published in January 2022, monitored global internet trends, and it concluded that internet search data could reliably predict COVID-19 outbreaks at both global and regional levels.. According to the Anxiety and Depression Association of America, a panic attack includes at least four of the following symptoms. Dealing with tiredness you just can't shake? Once gone, it leaves no lasting symptoms. How to Survive This Pandemic. A recent review of studies found that one in five COVID-19 patients reported, A funny feeling at the back of your throat can be easy to dismiss. Research published in February 2021 suggested people with GI conditions, such as Barretts esophagus, could have an increased risk of developing severe COVID-19. Federal government websites often end in .gov or .mil. Why do I feel pain after exercise? Disclaimer. It can really mimic so many types of symptoms - whether its affecting the pulmonary system or the musculoskeletal system or your health.". It can also be a sign of coronavirus. Certain factors can help determine the cause of stabbing chest pain. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. "COVID toes" may seem to be a weird sign of coronavirus, but skin problems are crazy-common: Up to 20% of people with COVID-19 report skin changes, such as a red, bumpy rash; hives; or breakouts resembling chickenpox. With so many heating pads on the market, our writer, who has a chronic pain condition, lists the products she loves. But if you're experiencing stomach issues, it may not be fear or the flu. A heart attack may cause a dull, crushing, or stabbing pain in the chest. If the disease can spread through feces, this could change current hygiene and self-isolation recommendations. Abdominal CT scan sh owing bilateral subpleural ground-glass opacities with intralobular reticulations at, CT scan showing predominantly right lower lobe crazy-paving associating ground-glass opacities and interlobular, MeSH Pleuritis, or pleurisy, is inflammation and irritation of the lining of the lungs and chest. Cochrane Database Syst Rev. Cardiovascular health: Insomnia linked to greater risk of heart attack. Causes of progressive abdominal pain include: Cancer. Its also important to note here that muscle pain is a potential symptom of long-haul COVID. When this pain comes and goes, a person may suspect a problem. Tenforde MW, et al. Heartburn is chest pain that occurs when stomach acid leaks out of the stomach and back up into the esophagus (food pipe). Covid-induced muscle pain is believed to be the result of inflammation. Some examples include: Learn about natural ways to reduce the symptoms of GERD. Researchers are investigating to uncover these causes. To report that patients who subsequently test positive for COVID-19 may present with acute abdominal pain and no pulmonary symptoms, although they already have typical lung lesions on computed tomography (CT) scan. It may radiate out to other areas of the body, such as: Other possible symptoms of a heart attack include. In addition to muscle pain, people with fibromyalgia may have: Chronic fatigue syndrome (CFS) is a condition thats characterized by feelings of overwhelming fatigue. Online ahead of print. Dos Santos PG, Vieira HCVS, Wietholter V, Gallina JP, Andrade TR, Marinowic DR, Zanirati GG, da Costa JC. Emerg Radiol. MNT is the registered trade mark of Healthline Media. She said shes grateful, but emotional after the eight days of isolation. eCollection 2021 Oct. Ebrahimzadeh S, Islam N, Dawit H, Salameh JP, Kazi S, Fabiano N, Treanor L, Absi M, Ahmad F, Rooprai P, Al Khalil A, Harper K, Kamra N, Leeflang MM, Hooft L, van der Pol CB, Prager R, Hare SS, Dennie C, Spijker R, Deeks JJ, Dinnes J, Jenniskens K, Korevaar DA, Cohen JF, Van den Bruel A, Takwoingi Y, van de Wijgert J, Wang J, Pena E, Sabongui S, McInnes MD; Cochrane COVID-19 Diagnostic Test Accuracy Group. every day. COVID-19 can cause a variety of symptoms that may appear gradually. Most side effects go away in a few days. Like many viruses, COVID can make you feel run down, even if you don't experience more obvious symptoms of the disease like a fever or cough. Some symptoms, such as cough and loss of smell and taste, may take longer to resolve. Ooi MWX, Liong SY, Baguley N, Sharman A, Tuck J. Clin Imaging. While we are focused on cough and fever as the initial signs of COVID-19, its also important to be aware that abdominal pain, vomiting and diarrhea could precede respiratory symptoms in some people. 6254a4d1642c605c54bf1cab17d50f1e. The news outlet also claimed that doctors suspect there may be something unique to Omicron about the way it affects the musculoskeletal system. If you received a vaccine that requires two doses (Pfizer or Moderna), side effects may be more intense after you get the second dose. This means that we may include adverts from us and third parties based on our knowledge of you. When to test for COVID-19 using real-time reverse transcriptase polymerase chain reaction: a systematic review. 4 Please enable it to take advantage of the complete set of features! (n.d.). Nausea and vomiting may be present in up to two-thirds of patients with COVID-19. Overall, 50% (8/16) of these patients had no intra-abdominal pathology on CT. Federal government websites often end in .gov or .mil. Previous studies have also reported on this "nocebo effect. On Wednesday, she was put on oxygen.I felt like someone was grabbing my lungs with their nails and just squeezing them so tight. Bethesda, MD 20894, Web Policies COVID-19 is everywhere, but it doesn't always shout to make its presence known. xhr.setRequestHeader('Content-Type', 'text/plain;charset=UTF-8'); The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Its currently unknown what exactly causes long-haul COVID. 2022 May 18. 9 Omicron symptoms believed to appear in fully vaccinated - early signs to look for, What is Deltacron? 2020;107(7):e186-e187. Omicron infection: What are the symptoms? Clipboard, Search History, and several other advanced features are temporarily unavailable. advice every day. And research suggests that the composition of the gut microbiota, the community of microbes that inhabit the intestines or stomach, can influence COVID-19. Can poor sleep impact your weight loss goals? We look at 18 causes and when to contact a doctor. Best food forward: Are algae the future of sustainable nutrition? New Study Says Unlikely, around someone with a confirmed COVID-19 infection, around a person with symptoms of COVID-19, in an area that was crowded or poorly ventilated, fatigue that gets worse with physical or mental exertion, feeling dizzy or lightheaded upon standing, fatigue, particularly after standing up or walking, pain and stiffness in the muscles and joints around the hips, neck, upper arms, or shoulders, numbness and tingling in the hands, feet, or face, doesnt go away after several days of at-home care. Mesquita RR, et al. HHS Vulnerability Disclosure, Help You May Develop Skin Problems. Michael Martin is a New York City-based writer and editor. Get the facts about the 2019 coronavirus (and COVID-19). Here are 13 human studies on coconut oil and its health effects. Study aims were to determine COVID-19 incidence in those with acute abdominal pain in the absence of respiratory symptoms and to assess the diagnostic performance of CT thoracic imaging in such patients. A Systematic Review of Abdominal Imaging Findings in COVID-19 Patients. These are most often related to lifestyle factors, including: Whether muscle pain is due to COVID-19 or not, see a doctor if youre having muscle pain that: If your muscle pain is due to COVID-19, seek immediate medical attention or call 911 if you have any of the following symptoms: If you have or suspect that you have COVID-19, be sure to let medical staff know either prior to or upon your arrival at a medical facility. Some scientists say skin rashes should be named a key sign of COVID-19, just as likely as fever, cough, or loss of smell or taste. And a report from October 2020 found that children with COVID-19 who develop GI symptoms were more likely to experience severe, critical infections and cardiac impairments. In the small study of 204 patients diagnosed with COVID-19 in the Hubei province of China, researchers noted that nearly 49% of these patients presented to the emergency department with gastrointestinal (GI) symptoms such as vomiting, diarrhea or abdominal pain. This process can allow viruses to affect the vagus nerve, causing nausea. And because the virus affects such a wide range of body systemsproducing everything from headaches to, The daily headlines make many of us queasy. I cover breaking news in medicine, med tech and public health. Joint pain. COVID-19 seems to have the potential to cause pain in a variety of ways, including damage to peripheral nerves causing neuropathy-like symptoms, by affecting pain pathways inside the brain,. Your intercostal muscles lie between your ribs. The pain may worsen when the person breathes in. If the second dose is also ineffective after 5 minutes, a person should phone the emergency services, as they may be experiencing a heart attack. These are symptoms that can last weeks or months after contracting COVID-19. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. A doctor can recommend a treatment plan thats appropriate for your condition. Coconut oil is a tropical fat that is claimed to have various benefits for health. First, take a COVID-19 test. NCI CPTC Antibody Characterization Program. Vaccines are intended to cause a response by the body, but doing so in the bursa will cause weeks of poor . A one-off bout of mild chest pain that passes quickly is unlikely to be a cause for concern. Physicians evaluating new GI complaints should consider COVID-19 and take appropriate precautions, explained Swaminath. Its also possible, but not yet confirmed, that the virus may directly infect muscle tissue. government site. Griffin spent her birthday in the hospital Saturday with nurses in full protective gear bringing her balloons. This is completely normal and is a sign that your body is working to build immunity. Normally, the stomachs high acidity levels are strong enough to deactivate viral particles. Patient findings from the work-up are shown in Table 1. In this Snapshot feature, we look at what we know about symptoms of infection with Omicron, home treatments, and prevention measures. Researchers are still learning how infection with SARS-CoV-2 affects different parts of the body. In this article, we outline some of the possible causes of intermittent stabbing chest pain, along with their associated symptoms and treatments. Is the ketogenic diet right for autoimmune conditions? When youve been fully vaccinated. What is the latest research on the form of cancer Jimmy Carter has? (2016). You can learn more about how we ensure our content is accurate and current by reading our. Experiencing an intermittent stabbing pain in the chest can be worrying, but there are many possible causes of this type of chest pain. 2022 Jul 12:31348221114033. doi: 10.1177/00031348221114033. throbbing or pulsing pain sensitivity to light, sound, smell, or touch nausea and vomiting People with COVID-19 who develop headaches also tend to develop: fever sore throat loss of taste loss. Results: On Monday, she was discharged. 'No clue I was sick': Woman who went to hospital with abdominal pains admitted with coronavirus, Horoscope for Saturday, 3/04/23 by Christopher Renstrom, West I-80 closed near Tahoe due to snow and 'multiple spinouts', Horoscope for Friday, 3/03/23 by Christopher Renstrom, Snowboarder dies at Tahoe ski resort following historic blizzard, Even Salesforces tower HQ isnt safe from office cuts, Wife of Jeffrey Vandergrift issues somber update, Mochi muffin bakery closes SF cafe after just 4 months, Oakland ransomware attackers leak 'confidential' data, The Warriors broke Russell Westbrook, just like old times. -, Huang C, Wang Y, Li X, et al.Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Get the best food tips and diet Common posture mistakes and fixes. Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network United States, March-June 2020. If the initial dose does not work within 5 minutes, a person should take a second dose. Controlled, double-blind, randomized trial to assess the efficacy and safety of hydroxychloroquine chemoprophylaxis in SARS CoV2 infection in healthcare personnel in the hospital setting: A structured summary of a study protocol for a randomised controlled trial. According to a study from Norway, people who have received two doses of a Covid vaccine have reported cough, runny nose, fatigue, sore throat, headache, fever, sneezing and nausea after being infected with Omicron. A. of 1,420 coronavirus patients found that 53% of them reported a sore throat. All rights reserved. All data and statistics are based on publicly available data at the time of publication. The condition can cause brief, sharp chest pain during bodily movements such as: Pleuritis can occur as a result of the following: The treatment for pleuritis depends on the underlying cause. Two examples of inflammatory myopathies are: One of the main symptoms of inflammatory myopathy is progressive muscle weakness. Learn about causes. There is some evidence that having GI symptoms of COVID-19 or developing the disease in addition to an underlying GI condition may increase the risk of COVID-19 severity and complications. xhr.send(payload); Epub 2020 Aug 15. The treatment for the many other causes of muscle pain depends on the cause itself. A recent review of studies found that one in five COVID-19 patients reported only gastrointestinal symptoms after being infected with the virus, such as loss of appetite, nausea, vomiting, diarrhea and abdominal pain. Data thus far indicates that people who typically require hospitalization arrive at the hospital within 7-9 days of onset of symptoms, with a peak in mortality seen at 3 weeks after initial symptoms.